【作者】 李玉艳； 武俊青； 周维谨； 高尔生；

【Author】 LI Yu-yan Wu Jun-qing Zhou Wei-jin Gao Er-sheng Shanghai Institute of Planned Parenthood Research,Shanghai,200032,China. School of Public Health,Fudan University

【机构】 上海市计划生育科学研究所/国家人口计生委计划生育药具国家重点实验室； 复旦大学公共卫生学院；

【摘要】 目的应用典型相关分析方法,分析中国成年男性血清微量元素锌、铜、锰、铅、镉与精液常规指标之间的相关关系。方法 2001年1月至2004年12月在河北、河南、山西、贵州、浙江和山东六省招募年龄在20～59周岁之间的合格研究对象,对其进行问卷调查、外生殖器检查、精液分析和血清微量元素检测。共纳入研究对象1179。采用典型相关分析方法探索血清微量元素与精液质量的关系。结果简单典型相关分析显示血清锌与精子存活率呈负相关,与正常形态精子率和前向运动精子率呈正相关;而血清铜的作用与锌相反,与精子存活率呈正相关,与正常形态精子率和前向运动精子率呈负相关。调整地区因素后的偏典型相关分析结果表明血清铜、锰与精子存活率呈正相关,与前向运动精子率呈负相关;血清锌、铅与精子密度和正常形态精子率呈正相关。结论在非职业接触成年男性中,血清锌、铜、锰与精液质量常规指标有一定的相关关系;未发现铅、镉对精液质量有不良影响。更多还原

【Abstract】 Objective To understand the correlation between serum trace elements and semen quality among male adults in China.Methods Eligible men aged from 20 to 59 years old were recruited in Hebei,Henan,Shanxi,Guizhou,Zhejiang and Shandong during Jan,2001 to Dec,2004.Questionnaire survey was conducted,and pudendum,semen quality and trace elements’ concentrations in serum were also examined.Canonical correlation analysis was used to explore the correlation between serum trace elements and semen quality.Results Single canonical correlation analysis showed that serum zinc had negative correlation with sperm viability,positive correlations with normal morphology and progressive motility, and that copper had opposite effects to zinc’s.After adjustment for region,we found that copper and manganese had positive correlations with sperm viability,and negative correlation with progressive motility, and that zinc and lead had positive correlations with sperm density and normal morphology.Conclusion Among no-occupational contact adult men,serum zinc,copper,manganese had some correlations with semen routine parameters,but no harm of lead and cadmium was found in this study.更多还原