【作者】 张琳； 田英； 崔昌； 王沛； 丁问微； 高宇； 王筱金； 施蓉； 王英； 金军； 金萍；

【Author】 ZHANG Lin~(1,2),TIAN Ying~(1,2),CUI Chang~(1,2),WANG Pei~3,DING Wen-wei~4,GAO Yu~1,WANG Xiao-jin~5,SHI Rong~1,WANG Ying~4,JIN Jun~4,JIN Ping~1. 1.Department of Environmental Health,School of Public Health,Shanghai Jiao Tong University,Shanghai, 200025,China.;2.Shanghai KeyLab of Children’s Environmental Health,Shanghai,200092,China;3.Pudong New Area,Shanghai Centre for Disease Control and Prevention,Shanghai,200136,China;4.College of Life and Environmental Sciences,Central University for Nationalities,Beijing,100081,China;5.Department of Biostatistic,School of Medicine,Shanghai Jiaotong University,Shanghai,200025,China.

【机构】 上海交通大学医学院公共卫生学院环境教研室； 上海市环境与儿童健康重点实验室； 上海市浦东新区疾病预防控制中心； 中央民族大学生命与环境科学学院； 上海交通大学医学院生物统计学教研室；

【摘要】 目的调查上海市城郊地区新生儿脐带血中多溴联苯醚（polybrominated diphenylethers,PBDEs）暴露水平,并分析胎儿期PBDEs暴露对新生儿出生结局的影响。方法于2006年9月至2007年4月,对上海市城郊地区某三级甲等医院50名入院生产的孕妇进行问卷调查,收集新生儿脐带血样本。使用气相色谱-负化学电离源-质谱法（GC-NCI-MS）检测脐带血中7种PBDEs（BDE-28,BDE-47,BDE-99,BDE-100,BDE-153,BDE-154和BDE-183）,计算PBDEs总浓度（∑₇PBDEs）。并进一步分析新生儿脐带血中PBDEs暴露水平对新生儿生长发育的影响。结果上海市城郊地区新生儿脐带血中∑₇PBDEs均数为56.65 ng/g lipid,中位数为14.06 ng/g lipid,范围为（1.03-379.73）ng/g lipid。新生儿Quetelet’s指数与BDE-99（r=-0.347,P<0.05）和BDE-154（r=-0.292,P<0.05）浓度有负相关性,并且BDE-99在低身长组（≤50 cm）和高身长组（>50 cm）之间有统计学差异（t=2.32,P=0.03）。结论上海市城郊地区新生儿脐带血中普遍存在PBDEs的暴露。脐带血中BDE-99和BDE-154高水平暴露可能导致新生儿Quetelet’s指数降低,并且BDE-99高水平暴露可能导致新生儿出生身长降低。故PBDEs暴露对新生儿出生结局的影响值得进一步关注。更多还原

【Abstract】 Objective Polybrominated diphenyl ethers（PBDEs） are widespread in China. Recent studies have demonstrated widespread exposure to PBDEs among susceptible populations including pregnant women in some cities in China.But little is known about levels of PBDEs exposure in the population of Shanghai and its potential adverse health effects.Methods We investigated both PBDEs exposure levels in umbilical cord serum and the effects of PBDEs exposure on fetal growth in Shanghai,China,enrolling 50 healthy pregnant women between September 2006 and April 2007.PBDEs exposure was assessed by a questionnaire administered to the mothers in the hospital after delivery as well as by analyzed seven PBDE congeners（BDE-28, -47,-99,-100,-153,-154 and -183） in umbilical cord serum.Medical records on birth weight, length,head and chest circumference were collected for the enrolled infants.Results The mean, median and range ofΣ₇PBDEs in umbilical cord serum were 56.65 ng/g lipid,14.06 ng/g lipid, and（1.03-379.73） ng/g lipid respectively.The top three PBDE congeners were BDE-99,BDE-100 and BDE-153,and the detection rates were 98%,72%and 76%respectively.The levels of PBDEs in umbilical cord serum of Shanghai were slightly higher than Guangdong,China,similar to the reports in South Korea and Spain,but much lower than that in U.S.A.In the assessment of the fetal growth,we found negative correlations between newborns’ Quetelet’s index and BDE-99（r = -0.347,P<0.05） and BDE-154（r = -0.292,P<0.05）.But the birth length,weight,head and chest circumference had no correlation with the PBDE congeners.Conclusion Our findings suggested that potential adverse health effects of utero PBDEs exposure should continue to be carefully studied in the future.更多还原