【作者】 张雪峰； 张军； 田华； 许可； 闫强； 夏宁邵； 朱凤才；

【Author】 ZHANG Xue- feng~1,ZHANG Jun~2,TIAN Hua~1,XU Ke~1,YAN Qiang~2,XIA Ning-shao~2,ZHU Feng-cai~1.1.Jiangsu Center for Disease Control and Prevention,Nanjing 210009,China;2.National Institute of Diagnostics and Vaccine Development in Infectious Diseases,Xiamen University,Xiamen 361005,China.

【机构】 江苏省疾病预防控制中心急性传染病防制所； 厦门大学,国家传染病诊断试剂与疫苗工程技术研究中心；

【摘要】 目的了解江苏省部分地区散发戊型肝炎病例的流行特征及病毒基因型。方法在江苏省部分地区开展为期1年的戊型肝炎病例监测,用ELISA法检测各医疗单位报告的急性肝炎病例进行血清学分型,对其中确诊为急性戊型肝炎病例进行流行病学分析以及HEV RNA检测和序列分析。结果男女戊肝病例比例为4.4:1,84.0%的病例集中在40岁及以上的年龄组,全年均有戊型肝炎病例发生,70.5%的病例集中在上年12月份至次年的4月份间;HEV基因分型检测结果为HEV-1型与HEV-4型所占比例分别为5.1%、94.9%。结论江苏省戊肝发病比例男性高于女性,多见40岁以上人群,冬春季节发病较高,戊型肝炎病毒株以HEV-4型为主。更多还原

【Abstract】 Objective To investigate the epidemiologic characteristics and the genotype of hepatitis E in Jiangsu Province.Methods Patients with acute sporadic hepatitis were collected,anti-HEV-IgM were tested by commercial ELISA kits,and the RT-PCR method was applied to obtain the sequence of HEV.Results 84.0%sporadic hepatitis E cases occurred with age over 40,the male to female ratio was 4.4:1,70.5%cases occurred from December to April;the HEV type 1 and type 4 co-existed,but the HEV type 4 was proved to be the main type(94.9%).Conclusions The cases with hepatitis E were more frequent in male than in female,most of cases occurred with age over 40,rose up in winter and spring,the HEV type 4 was the main type.更多还原