【作者】 赵博； 冯秀萍； 李建国； 陈芳； 吴大梅； 张晓蓉；

【Author】 Zhao Bo,Feng Xiu-Ping,Li Jan-Guo,Chen Fang,Wu Da-Mei,Zhang Xiao-Rong (School Basic Medicine,Guiyang University of TCM)

【机构】 贵阳中医学院基础医学部；

【摘要】 目的:观察慢性轻度不可预见应激抑郁症模型大鼠行为学及血清T₃、T₄、TSH的变化。方法:采用慢性不可预见轻度应激抑郁症动物模型（CUMS）,设正常组、模型组、氟西汀组、抗郁散大、中、小剂量组,测定各组大鼠体重、糖水消耗量及行为学改变,并用放免法测定大鼠血清T₃、T₄、TSH含量的变化。结果:模型组大鼠血清T₄的含量显著升高、TSH的含量升高,有显著性差异（P<0.05）;T₃的含量降低,无显著性差异（P>0.05）;与模型组相比,抗郁散大、小剂量组和氟西汀组,血清T₄值显著降低,TSH值降低,有显著性差异（P<0.05）,而T₃的值降低,无显著性差异（P>0.05）;与模型组相比抗郁散中剂量组大鼠血中清T_4TSH的含量显著降低、T₃的含量明显升高,差异有显著性（P<0.05）。结论:抗郁散使血清T₃值含量升高、T₄、TSH值含量降低,其机制可能与抗郁散调节HPT轴功能紊乱有关。更多还原

【Abstract】 Objective:To observe the levels of serum thyroid hormone（T₃,T₄ TSH）in chronic unpredictable mild stress（CUMS） rat model and investigate the effects of HPT axis of patient with depression using antidepressant.Methods:We performed randomized 60 rats to control,model,Fluoxetine and Kangyusan gruops（large,normal and small）.The serum levels of T₃,T₄,TSH were determined with radioimmunoassay and rat body weight,sugar consumption and behavior change in all groups.Results:Compared with the control group,levels of serum T₄,TSH in model group were increased, and T₃ were decresced significantly（P<0.05）;lost weight,vertical and horizontal reduction in the number of sports,to reduce consumption of dessert,there is significant difference,model group,serum 7,levels were significantly increased,TSH levels rise,there is significant difference（P<0.05）;Compared with model group, levels of serum T₄,TSH in antidepressants large,normal and small group and the Fluoxetine group were decreased and T₃ were increased significantly（P<0.05）.Conclusions:Antidepressants could improve and regulate the function of HPT axis,so that the mechanism of antidepressants may be associated with regulation of HPT axis.更多还原