慢性心衰患者氨基末端脑钠肽前体、血浆肌钙蛋白Ⅰ、高敏C反应蛋白检测的临床应用

【作者】 林敏瑜； 刘菁； 辛福顺； 郑伯仁； 林绍彬；

【机构】 福建医科大学附属教学医院福州市第二医院心内科；

【摘要】 目的:探讨心力衰竭(HF)时氨基末端脑钠肽前体(NT-pro-BNP)、肌钙蛋白I(cTnI)、高敏C反应蛋白(hs-CRP)临床预后意义。方法:83例临床诊断为心力衰竭患者,根据心功能不同的级别分为Ⅱ级,Ⅲ级,Ⅳ级,应用超声心动图测定左心室射血分数(LVEF),左室舒张末期内径(LVDd),并分别抽取静脉血测定NT-pro-BNP,cTnI,hs-CRP值,7天后复查上述各值。其中72例随访9-12个月以了解心脏事件发生与NT-pro-BNP,cTnI,hs-CRP关系。结果:随着CHF程度加重,NT-pro-BNP及治疗后cTnI,hs-CRP水平均升高,3组间差异有统计学意义(p值<0.01),CHF患者入院早期NT-pro-BNP及cTnI,hs-CRP单项检测与三项联合检测比较,联合检测敏感性优于单项检测,随访患者发生心脏事件与非心脏事件与治疗后NT-pro-BNP下降>30%及cTnI,hs-CRP水平相关(p值<0.01)。结论:NT-pro-BNP,cTnI,hs-CRP在诊断心衰和评估预后有临床意义。更多还原

【Abstract】 Objective To explore clinical diagnostic and prognostic value of NT-brain-natriuretic peptides(NT-pro-BNP ),serum high-sensitive C-reactive protein (hs-CRP),cardia troponin I(cTnI) in patients with heart failure(HF).Methods Totally 83 clinic diagnosed HF patients of different etiology and different classification of cardiac function were enrolled into this study.NT-pro-BNP,hs-CRP,cTnI levels were measured in all patients when they admitted to hospital,7 days after treatment and at hospital discharge.The patients were followed up to be observed the recurrence of cardiac events.Results In the HF patients with different classification of cardiac function,NT-pro-BNP(admission and after 7 days of treatment),hs-CRP,cTnI levels were compared,the differences were statistically significant.The joint measurement was better than a single measure(p<0.01).The NT-pro-BNP level docreased over 30%,cTnI level were related with the group of follow up cardiac events. Conclusions The clinical diagnosis and prognosis of the three combined measurements in patients with HF have important significance.更多还原