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广州地区高危新生儿脐血IgE对婴幼儿过敏疾病的预警研究

Predictors of atopy using cord blood I gE levels in Guangzhou District

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【作者】 黄志坚黄翠玲邹红梅邓冉郭彩娇赵小朋吕俊健叶诏伟高健群陈励和

【Author】 HUANG Zhijian,HUANG Cuiling,ZOU Hongmei,DENG Ran,GUO Caijiao,ZHAO Xiaopeng,LU Junjian,YE Zhaowei, GAO Jianqun,CHEN Lihe. Women and Children’s Hospital of Guangzhou,Guangzhou 510180

【机构】 广州市妇婴医院

【摘要】 目的:探索本地区新生儿不同脐血IgE水平对婴幼儿过敏疾病的预警可行性。方法:随机选取本院出生的足月、自然分娩新生儿,对脐血IgE不同水平的人群,进行为期三年的观察;主要观察消化系统、皮肤和呼吸系统等组织器官的过敏反应症状和体征;使用瑞典法玛公司生产的UniCap100型测定仪,以及脐血IgE检测试剂盒,以荧光酶免疫方法测定脐血IgE的含量。结果:本组病例在观察过程中证实患有过敏性疾病41例,占23.29%(41/176)。在患病婴儿中湿疹占46.34% (19/41),牛奶过敏占19.56%(9/41),哮喘占19.56%(9/41),过敏性鼻炎占19.51%(8/4.1),荨麻疹占14.63%(6/41)。有家族过敏史者患病占86.66%(13/15)。患病与非患病两组新生儿CBIgE水平比较有统计学意义,p<0.001,不同CBIgE界值的预报结果以CBIgE 1.08kUA/L为优,敏感性为80.49%,特异性为74.07%,准确性为75.57%。结论:脐血IgE可以预警婴幼儿过敏疾病,1.08kUA/L界值可以作为本地区婴幼儿过敏疾病的预警指标。

【Abstract】 Objective:To evaluate whether different cord blood IgE(CBIgE)level in our district could be used as a predictor of young children’s allergic diseases.Methods:The present study randomly enrolled term infants naturally born in our hospital who were in different cord blood IgE level,the author followed up those infants for three years and observed allergic response of digestive system, respiratory system,skin and other organs.The IgE level of cord blood was measured with fluoroscopic enzyme-immune method using UniCap-100 equipment of Sweden Pharmacia company.Results:Among 176 cases,41 cases(23.29%)are confirmed suffering from allergic diseases.Eczema accounts for 46.34%(19/41),the milk allergy accounts for 19.56%(9/41),asthma accounts for 19.56%(9/41),the allergic rhinitis accounts for 19.51%(8/41),the nettle rash accounts for 14.63%(6/41),a family history of allergy patients accounts for 86.66%(13/15).Compare with the group with allergic disease and the group with non-allergic disease,the CBIgE level have a statistical difference(p<0.001),Compared with different CBIgE value,the best predictor value of CBIgE is 1.08kUA/L with the sensitivity of 80.49%,the specificity of 74.07%and the efficiency of 75.57%.Conclusion:CBIgE level can predict future children’s allergic diseases,the value of 1.08kUA/L can be regard as a good predictor index in our district.

【关键词】 新生儿,脐血IgE过敏疾病
【Key words】 infantcord blood IgEallergic disease
  • 【会议录名称】 第四届中国中西医结合变态反应学术会议论文汇编
  • 【会议名称】第四届中国中西医结合变态反应学术会议
  • 【会议时间】2009-04-02
  • 【会议地点】中国陕西西安
  • 【分类号】R725.9
  • 【主办单位】中国中西医结合学会、中国中西医结合学会变态反应分会
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