【作者】 陈玲； 徐英； 潘建春；

【Author】 CHEN Ling~1,XU Ying~2,PAN Jian-chun~1 (1.Institute of Experimantal Neurobiology,Wenzhou Medical College,Wenzhou 325035,China;2.Department of Behavioral Medicine & Psychiatry,West Virginia University,Morgantown,WV 26506,USA)

【机构】 温州医学院实验神经生物学研究所； Department of Behavioral Medicine & Psychiatry,West Virginia University；

【摘要】 磷酸二酯酶(PDE)催化水解cAMP和cGMP,是细胞内降解cAMP和cGMP的唯一途径。PDE是一个多基因大家族酶,包含11型不同家族,它们的结构,分布以及调节方式对抑制剂的敏感性都不同。PDE选择性抑制剂可通过抑制cAMP或cGMP水解来调节学习记忆障碍等中枢神经系统疾病。因此,PDE被认为在中枢神经系统疾病的治疗上具有重要地位。本综述介绍目前PDE参与学习记忆障碍这一中枢神经系统疾病调节的研究进展,而且PDE作为中枢神经系统疾病的治疗靶点,研究其选择性抑制剂具有重要的意义。更多还原

【Abstract】 Phosphodiesterases(PDEs) are a super-family of enzymes that are involved in the regulation of the intracellular second messengers cAMP and cGMP by controlling their rates of hydrolysis.There are 11 different PDE families,and each family has typically multiple isoforms and splice variants.The PDEs differ in their structures, distribution,modes of regulation,and sensitivity to inhibitors.Since PDEs have been demonstrated to play distinct roles in the process of emotion,and related learning and memory,selective PDE inhibitors,by preventing the breakdown of cAMP and/or cGMP,could modulate mood and related cognitive activity.This review discusses the current status and future development in the burgeoning field of PDEs in the central nervous system.It is becoming increasingly clear that PDE inhibitors have therapeutic potential for the treatment of neuropsychiatric disorders involving disturbances of mood,emotion,and cognition.更多还原