【作者】 韩平平； 蔡慧明； 周美艳； 张明阳； 刘亚君； 郭继龙； 吴克俭； 戴体俊；

【Author】 HAN Pingping,CAI Huiming,ZHOU Meiyan,et al. Department of Pharmacy,Xuzhou Medical College,Xuzhou 221002

【机构】 徐州医学院药学院； 徐州医学院麻醉学院； 徐州医学院附属医院； 徐州医学院麻醉药理教研室；

【摘要】 目的观察戊巴比妥钠对兔定量药物脑电图（QPEEG）δ、θ频段的影响。方法采用QPEEG功率谱分析法,分析静注戊巴比妥钠30 mg·kg^-1前后δ、θ频段功率百分比的变化。结果与基础值相比,各脑区的δ频段功率百分比在给药后30 s,1、2、3、5、10 min时均增大（P<0.01）;θ频段功率百分比,给药后30 s、1、2、3、5、10 min时均降低（P<0.01,P<0.05）;与基础值波幅相比,给药后δ波幅明显增高。结论戊巴比妥钠能够增大δ频段功率百分比,降低θ频段功率百分比。更多还原

【Abstract】 Objective The purpose of this study was to observe the effects of sodium pentobarbital onδ-band andθ-band of quantitative pharmaco-electroencephalography in rabbits.Methods Sodium pentobarbital 30 mg·kg^-1 was injected to the rabbits.The EEG samples were obtained before and at regular intervals following the sodium pentobarbital injections.Using power spectral analysis to check 5,6 band power changes in the percentage before and after the sodium pentobarbital iv injections.Results Compared with the baseline,the percentage of theδband power increased significantly after 30 s～10 min of administration（P < 0.01）; compared with the previous administration,the percentage of theθband power were significantly decreased after administration 30 s,1、2、3、5、10 min（P < 0.01,P < 0.05）. Compared with the baseline amplitude,amplitude 8 increased significantly after administration.Conclusions Sodium pentobarbital increase the percentage of 8 band power and reduce theθband power percentage.更多还原