【作者】 杨劲； 方静；

【Author】 FANG Jing~1,YANG Jin~(2*) 1 Institute of Chemical Industry of Forest Products,CAF;Key and Open Lab.on Forest Chemical Engineering,SFA,Nanjing 210042,China;2Center of Drug Metabolism and Pharmacokinetics China Pharmaceutical University,Nanjing 210009,China

【机构】 中国药科大学药代中心； 中国林业科学研究院林产化学工业研究所； 国家林业局 林产化学工程重点开放性实验室；

【摘要】 目的:以法罗培南为例介绍蒙特卡洛模拟法对时间依赖性抗生素进行PK/PD研究。方法:采用已有的12名健康志愿者饮食及空腹后服用法罗培南的群体药代动力学参数,运用蒙特卡洛法分别模拟1000条药-时曲线。用BAPP3.0计算每条药-时曲线的血药浓度大于最小抑菌浓度（MIC）的时间(T_>MIC)与给药间隔的比值。结果:对于不同的MIC值,空腹组的T_>MIC值均大于饮食组。但对于MIC值较大的细菌,药效偏低,提示可以增加给药剂量。结论:与空腹给药相比,在本实验给药方案下,高脂饮食可能会降低法罗培南的疗效。更多还原

【Abstract】 Objective:To study the PK/PD of faropenem with the use of Monte Carlo Simulations. Methods:According to the population pharmacokinetic parameters of 12 health volunteers given faropenem under the conditions of fasting and non-fasting,each group simulate 1000 curves of Conc.-time using the Monte Carlo Method,then calculate the T_>MIC with the program of BAPP3.0,and compare the difference between the two groups.Results:For different MIC,the T_>MIC of fasting group are larger than that of non-fasting group.It suggests to double the dosage for the%T_>MIC is too small when MIC is bigger than 0.125.Conclution:Compared with the fasting group,high-fat meal may decrease the effect of faropenem under the dosage regimen of the study.更多还原