【作者】 贺福元； 邓凯文； 邹欢； 邱云； 陈锋； 周宏灏；

【Author】 Fu-Yuan He~(1,2),DENG Kaiwen~3 ZOU Huan~2 QIU Yun~2 CHENG Feng~2 Hong-Hao Zhou~1 (1.Pharmacogenetic Research Institute,Institute of Clinical Pharmacology,Central South University Changsha(410078);2 Department of Pharmaceutics,Hunan University of Tradition Chinese Medicine Changsha(410208)) 3.The First Affinity Hospital,Hunan University of Tradition Chinese Medicine Changsha(410007),China)

【机构】 中南大学临床药理研究所； 湖南中医药大学附一医院； 湖南中医药大学药学院；

【摘要】 目的:对中药多成分体系谱动学与谱效动学的数学模型及参数差异进行研究,回答中药多成分药物动力学参数能否指导中药临床用药问题。方法:在已建立的中药四谱学事论基础上,主要对谱动学与谱效动学的数学模型及参数的差异进行对比分析,找出其特点与应用条件。结果:从定量药理学的角度,分析了单成分与中药多成分药物动力学,药效动力学的函数表达、零、一、二阶矩的通用式及运算结果,总量药物动力学参数由单个成分的药物动力学参数决定,总量药效动力学参数由单成分的药物动力学参数与药效系数共同决定,当中药各成分的构成比决定了,各成分的效应系数一定时,药效动力学参数与药动力学参数对应。结论:中药药效决定于药物动力学参数及效应系数。单成分药物动力学参数能独立指导药物临床用药是谱效动学的特例,不适用于多成分体系。不能之来解决中药多成分的谱动学的问题。更多还原

【Abstract】 Objective:To study on the differences between chromatokinetics,and chromatodynamikinetics with Fingerprint Chromatography to answer the question whether the pharmacokinetic parameters of multiple composites can be utilized to guide the medication of multiple composites.Methods:On the base of established four chromatopharmacology (pharmacology with chromatographic fingerprint),the chromatokinetics,and chromatodynamics had analyzed comparably on their mathematical model and parameter definition.Results:On the quantitative pharmacology,the function expressions and total statistical parameters,such as total zero moment,total first moment,total second moment of the chromatokinetics,and chromatodynamics were analyzed to the common expressions and elucidated results for single and multiple composites.Total quantitative pharmacokinetic parameter were decided by each composite pharmacokinetic parameters,whereas the total quantitative pharmacodynamic parameter were decided by both of each pharmacokinetic pharmacodtnamic parameters of each composites.The pharmacokinetic parameters were correspond to pharmacodynamic parameters with a existing stable effective coefficient when the constitutive ratio of each composites was a constant Conclusion:The effects of Chinese Medicine were controlled by pharmacokinetic and pharmacodynamic parameters.It is a special case that the pharmacokinetic parameter could independently guide the clinical medication whereas the pharmacokinetic parameters are not applied to the multiple composite drug combination system,and not be used to solve problems of Chromacokinetics of Chinese Medicine.更多还原