【作者】 罗素霞； 陈小兵； 韩丽黎； 高晓会； 李宁； 邓文英； 周孟强； 索振河；

【Author】 Luo Su-xia~(1,2),Chen Xiao-Bing~(1,2),Han Li-li~2,Gao Xiao-hui~3,Li Ning~2, Deng Wen-ying~2,Zhou Meng-qiang~2,Suo Zhen-he~1 1 Oncology Department of the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China;2 Internal Department of Henan Tumor Hospital,Zhengzhou 450008,Henan Province,China;3 Department of Medical Oncology,First Affiliated Hospital, Henan University of Science and Technology,Luoyang,471003,Henan Province,China

【机构】 郑州大学第一附属医院肿瘤科； 河南省肿瘤医院内科； 河南科技大学第一附属医院肿瘤内科；

【摘要】 目的:观察并比较多西他赛(docetaxe,DOC)联合卡培他滨(Capecitabine,CAPE)与奥沙利铂(Oxaliplatin,L-OHP)联合CAPE治疗老年晚期胃癌的近期疗效和毒副反应。方法:82例老年晚期胃癌患者随机分为两组,A组38例应用DOC联合CAPE,B组44例应用LOHP联合CAPE,21天一个周期,均化疗2周期以上。结果:82例均可评价,A组有效率(CR+PR)为52.63%,中位无进展生存期(PFS)为6.1个月,B组有效率(CR+PR)为54.55%,B组PFS为6.3个月。两组副反应主要为骨髓抑制和胃肠道反应。A组骨髓抑制较重,B组神经毒性较重。均无化疗相关性死亡。结论:多西他赛联合卡培他滨与奥沙利铂联合CAPE两组方案对老年晚期胃癌患者疗效相当,副反应可以耐受。更多还原

【Abstract】 Objective:To observe and compare the recent objective response rate and toxicity of docetaxe(DOC) or oxaliplatin(L-OHP) combined with capecitabine(CAPE) in the treatment of olderly advanced gastric cancer.Methods:Eighty-two olderly patients with advanced gastric cancer were randomized and divided into two groups.Goup A consisted of 38 patients who received DOC plus CAPE and Group B with 44 patients received L-OHP plus CAPE in a 21-day regimen.Two or more cycles chemotherapy were completed in each group.Results:Eighty-two patients were assessable for efficacy and toxicities.In group A and B,the response rate(CR+PR) was 52.63%and 54.55%,respectively.The median progression-free survival(PFS) in group A(6.1 months) was similar to that in group B(6.3 months).The most common adverse effects were myelosuppression and gastrointestinal response in 2 groups.Patients in group A experienced more myelosuppression.On the contrary,the rate of mild neurotoxicity in group B was more increased. No chemotherapy-related death was observed.Conclusions:The effects of DOC or L-OHP combined with CAPE in the treatment of advanced gastric cancer are comparable and appropriate with a well tolerance.更多还原