【作者】 张珂； 杜民； 陈旭海；

【Author】 Zhang Ke,DU Min,CHEN XuHai(Fujian Key Lab of Medical Instrument & Pharmaceutical Technology,Fuzhou 350002,China)Institute of Pricise Instrument,FuZhou University

【机构】 福建省医疗器械和医药技术重点实验室；

【摘要】 急性早幼粒细胞白血病(APL)和慢性粒细胞白血病(CML)的早期诊断关系到患者的治疗效果与生存质量,因此急需一种能够准确检测病人血液中该特定致病DNA序列的专用仪器。本文简要介绍了一款自主研发的DNA电化学分析仪,并对其中所涉及到的滤波模块进行了详细介绍。鉴于FIR滤波算法在处理此类信号时的稳定性高,线性相位特性好,实时性强等特点,该信号滤波模块采取由现场可编程模拟阵列(FPAA)实现的有源二阶低通滤波器和FIR数字滤波器相结合的方式构成,其中软件滤波部分由DSPTMS320F2806实现。经测试,仪器的实际滤波效果能够满足实际电化学分析中的精度要求。更多还原

【Abstract】 The early diagnosis for acute promyelocytic leukemia(APL)and chronic myeloid leukemia(CML)is related to patient’s treatment outcomes and quality of life,so it need a specific instrument to detect the specific DNA sequences of the specific disease in the patients’ blood.This paper introduces a self-developed electrochemical DNA analyzer,which involved filtering module in detail.View of the FIR filter algorithm’s high stability,fine linear phase characteristic and real time characteristics in dealing with such signal,the signal filtering module is achieved by the combination of second-order low-pass active filter module implemented by Field Programmable Analog Array(FPAA)and FIR digital filter module that achieved by DSPTMS320F2806.After testing,the actual filtering result of the equipment can meet the accuracy requirements in actual electrochemical analysis.更多还原