Effects of pH and temperature on the structural and thermodynamic character ofα-synl2 peptide in aqueous solution

【作者】 曹赞霞； 刘磊； 王吉华；

【Author】 Zanxia Cao~(1,2),Lei Liu~3,Jihua Wang~(1,2*) 1Key Lab of Biophysics in Universities of Shandong(Dezhou University),Dezhou,China,253023 2Department of Physics,Dezhou University,Dezhou 253023,China 3Department of Computer Science and Technology,Dezhou University,Dezhou 253023,China

【机构】 山东省高校生物物理重点实验室(德州学院)； 德州学院物理系； 德州学院计算机系；

【摘要】 <正>Humanα-synuclein protein,a presynaptic protein of 140 amino acid residues,is the major component of Lewy bodies(LBs) deposited in the brains of patients with Parkinson’s disease,and it usually has extensive intrinsically disordered(ID) regions (IDRs).Typical of Parkinson’s disease is the presence ofα-synuclein aggregates in the form ofβ-structure that can be soluble or insoluble. Hu et al had reported that the N-terminal 12更多还原