【作者】 杨剑芳； 刘伟成； 张涛涛； 董丹； 裘季燕；

【Author】 Yang Jian-fang,Liu Wei-cheng,Zhang Tao-tao,Dong Dan,Qiu Ji-yan (Institute of Plant and Environment Protection,Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097)

【机构】 北京市农林科学院植物保护环境保护研究所；

【摘要】 放线菌尤其是链霉菌是来源于微生物的生物活性天然化合物的主要产生菌,其中的吸水链霉菌及其变种能产生大环内酯类、氨基糖苷类、苯醌型安莎类等抗生素及谷氨酰胺转胺酶等重要活性代谢产物,具有很高的新型药物开发潜力及微生物资源应用价值。本文对吸水链霉菌产生抗菌活性物质提取分离方法进行了综述,并对发展趋势进行了展望。更多还原

【Abstract】 Natural microbial active principles were mainly derived from actinomycetes,especially from streptomyces.Streptomyces hygroscopicus and its variants produced many active metabolites such as macrolides, aminoglycosides,benzenic ansamyeins and transglutaminase and had high potential for new drug development and application prospect of microbial resources.In this paper,the extraction and separation technologies of antibiotics from S.hygroscopicus were reviewed and the research trends were discussed.更多还原