【作者】 赵明； 王军波； 刘志刚； 张佳丽； 梁江； 赵海峰； 李琼； 张召锋； 李勇；

【Author】 Ming Zhao Zhigang Liu Jiali Zhang Jiang Liang Haifeng Zhao Qiong Li Zhaofeng Zhang Junbo Wang Yong Li (Department of Nutrition and Food Hygiene,School of Public Health,Peking University Health Science Center,Beijing 100191,China)

【机构】 北京大学公共卫生学院营养与食品卫生学系；

【摘要】 目的:研究口服核苷酸对实验性高脂血症大鼠血脂水平的影响。方法:选用60只健康雄性SD大鼠分成正常对照、高脂模型对照和0.04g/kg体重、0.16g/kg体重、0.64g/kg体重核苷酸组,正常对照组大鼠喂饲普通饲料,高脂模型和核苷酸组大鼠饲喂高脂饲料。核苷酸组大鼠以灌胃方式给予不同剂量的核苷酸(1ml/100g)45天,测定血清清总胆固醇、甘油三酯、高密度脂蛋白胆固醇含量。结果:摄入核苷酸45天后,0.04g/kg体重、0.16g/kg体重、0.64g/kg体重组大鼠血清总胆固醇(TC)分别为3.14±1.45mmol/L、3.65±1.58mmol/L、3.14±1.70mmol/L,0.04g/kg体重组及0.64g/kg体重组与高脂模型对照组(4.26±1.96mmol/L)相比显著降低;甘油三酯(TG)含量分别为0.93+0.53mmol/L、0.93±0.44mmol/L、0.72±0.38mmol/L,0.64g/kg体重组与高脂模型对照组(1.29±0.49mmol/L)相比显着降低;高密度脂蛋白胆固醇(HDL-C)分别为1.19±0.31、1.22±0.31、1.26±0.36,与高脂模型对照组(1.09±0.16mmol/L)相比无显着差异。结论:口服核苷酸具有一定的辅助降血脂功能,并提示其对动脉粥样硬化的发生具有一定的预防作用。更多还原

【Abstract】 Objective To determine the effects of dietary nucleotides(NT)on serum lipids in hyperlipidemic rats.Methods 60 healthy male SD rats were divided into 5 groups,which were normal control(NC)group, hyperlipidemic model control(HC)group and 0.04,0.16,0.64g/kgbw NT groups,NT were orally administered by gavage to rats in NT groups for 45 consecutive days(1ml/100gbw per day),and the control rats were given vehicle only,all animals except NC rats were fed with a high fat diet.The levels of serum total cholesterol(TC),triglyceride and low-density lipoprotein cholesterol(LDL-C)were measured.Result the levels of serum total cholesterol(TC) in 0.04,0.16,0.64g/kgbw NT groups were 3.14±1.45mmol/L,3.65±1.58mmol/L、3.14±1.70mmol/L respectively,the groups of 0.04 and 0.64g/kgbw had significantly lower level than that in HC group(4.26±1.96mmol/L);triglyceride(TG)levels in 0.64g/kgbw NT group(0.72±0.38mmol/L)were reduced significantly compared with that in HC group(1.29±0.49mmol/L);the low-density lipoprotein cholesterol(LDL-C)levels in each groups didn’t have significant difference.Conclusion Dietary nucleotides should have lipid-lowing effects,and might play a preventive role in hyperlipi-demia.更多还原