【作者】 赵红； 张清媛；

【Author】 Hong Zhao, Qingyuan Zhang Department of Internal Medicine,The Tumor Hospital of Harbin medical University, Harbin, Heilongjiang Province, China. 150086

【机构】 哈尔滨医科大学附属肿瘤医院；

【摘要】 目的:灵芝孢子粉作为一种传统中药,已广泛用于多种疾病的治疗。本研究的目的是探讨灵芝孢子粉可否改善接受内分泌治疗乳腺癌患者的癌相关性疲劳。方法:共有48名进行内分泌治疗具有癌相关性疲劳症状的乳腺癌患者参与本研究。这些患者被随机分为实验组和对照组。实验组患者接受口服灵芝孢子粉1000mg/次,一天三次,共四周的治疗。对照组服用安慰剂治疗。在基线及治疗后,患者进行癌症治疗相关疲乏功能评估表(FACIT-F),焦虑及抑郁量表(HADS),生活质量问卷表(QLQ-C30)的评估。临床干扰前后,将对患者血液中的TNF-α和IL-6的浓度,以及肝肾功能进行检测。应用配对检验及回归分析对数据进行统计学分析。结果:FACT-F评估结果显示,与对照组相比,患者接受灵芝孢子粉治疗后身体状况评分及疲劳程度评分均明显升高(分别为P<0.01及P<0.01)。HADS及EORTCQLQ-C30结果显示,实验组患者的焦虑及抑郁程度降低及生活质量满意度增高(分别为P<0.01和P<0.01)。实验组患者血液中TNF-α(71.89±10.76pg/ml)及IL-6(37.62±13.36pg/ml)浓度较用药前明显降低(分别为P<0.01andP<0.05)。本研究过程中没有严重不良反应发生。结论:灵芝孢子粉可改善接受内分泌治疗乳腺癌患者的癌相关性疲劳程度,其确切的作用机制有待进一步的研究阐明。更多还原

【Abstract】 Subject: Spore powder of Ganoderma Lucidum is a widely used traditional medicine in China.The aim of this study was to investigate the effectiveness of Spore of Ganoderma Lucidum for cancer-related fatigue in breast cancer patients undergoing endocrine therapy.Methods: 48 breast cancer patients with cancer-related fatigue undergoing endocrine therapy were randomized into an experimental or a control group.Patients in the experimental group were treated with Spore powder of Ganoderma Lucidum 1000mg,three times a day and patients in control group received placebo for 4 weeks.Functional Assessment of Cancer Therapy–Fatigue (FACT-F),Hospital Anxiety and Depression Scale (HADS),EORTC Quality Of Life Questionnaires (QLQ-C30) data were collected at baseline and after the Spore powder of Ganoderma Lucidum treatment.The concentrations of TNF-α,IL-6 and Liver-kidney functions were measured before and after intervention.The data was analyzed using Paired Samples Test and linear regression analysis.Results: Compared with control group,the experimental group showed statistically significant improvements in the domains of physical well-being (mean,24.62) and fatigue subscale (mean,46.78) which were assessed by FACT-F (P < 0.01 and P < 0.01,respectively).These patients also reported less anxiety and depression,better quality of life according to the outcomes of HADS and EORTC QLQ-C30 (P < 0.01 and P < 0.01,respectively).The concentrations of TNF-α (71.89±10.76 pg/ml) and IL-6 (37.62±13.36 pg/ml) of patients in experimental group were significantly lower at the end of treatment(P<0.01 and P<0.05,respectively).No serious adverse effects occurred during the study.Conclusions: The results of this study indicate that Spore powder of Ganoderma Lucidum may have beneficial effects on cancer-related fatigue and quality of life in breast cancer patients undergoing endocrine therapy.More rigorous trials are needed to confirm the efficacy of Spore of Ganoderma Lucidum.更多还原