【作者】 申兴斌； 金小平； 王瑞婷； 李瑞香； 于再东；

【Author】 Department of Pathology,Affiliated Hospital,Chengde Medical college, (Chengde 067000) SHEN Xing-Bin,WANG Rui-Ting,JIN Xiao-Ping etal

【机构】 承德医学院附属医院；

【摘要】 目的探讨VEGF及其受体FIk-1的表达与大肠癌临床病理特征问的关系,了解其在大肠癌中表达的意义。方法:采用免疫组化技术检测81例大肠癌(CC)中VEGF及FIk-1的表达。结果:VEGF及FIk-1的表达与大肠癌的浸润深度、淋巴结转移、远处转移、Dukes分期呈正相关。VEGF与FIk-1表达呈正相关。结论:VEGF及FIk-1促进了大肠癌组织的生长和转移,具有协同作用,可作为大肠癌的预后评估因子,联合检测以上指标对评估大肠癌的预后可能更准确。降低VEGF及FIk-1的表达和活性可能成为抗肿瘤转移治疗的一个新途径。更多还原

【Abstract】 Objective To explore the relationships between VEGF,Flk-1 expression and biological behaviors in CC. Methods:SP immunohistochemical staining was used to examine expressions of VEGF,Flk-1 among 81 cases of CC paraffin-embedded specimens.Rank sum test was used to analyze the expressions of VEGF,Flk-1.ResultsDVEGF and Flk-1 expression in CC were also positively correlated with depth of invasion(P<0.01),lymph node metastasis(P<0.01), distant metastasis(P<0.01),Dukes’ stage.Positive relationship appeared between VEGF and Flk-1.ConclusionD VEGF,Flk-1 maybe improve the growth and metastasis of CC.They could be prognostic factor of CC.Decreasing the expression and activity of VEGF,Flk-1 might be new pathway for CC treatment.更多还原