【作者】 吕喜英；

【Author】 LV Xi-ying Department of Oncology,Affiliated Hospital of Cheng-de Medical College(067000),Hobe Province,067000,P R China

【机构】 承德医学院附属医院肿瘤内科；

【摘要】 目的探讨Survivin和CD105肺癌组织中的表达与预后的关系。方法应用免疫组化检测了35例化疗组和35例非化疗组的肺癌患者中Survivin和CD105的表达水平,比较Survivin和CD105的表达与生存率的关系。结果 Survivin和CD105在肺癌中的阳性表达率分别为74.3%和67.1%,二者呈正相关,P=0.000;化疗组Survivin和CD105不同表达的患者与非化疗组的中位生存时间(MST)有明显差异;化疗组中Survivin、CD105表达阴性者生存时间明显长于阳性表达者。结论 Survivin与CD105在肺癌组织中表达是化疗疗效、预后的判断具的重要指标。更多还原

【Abstract】 Objective:To study the relationship between the expression and prognosis of Survivin and CD105 in lung cancer.Methods:Survivin and CD 105 were detected by immunohischemistry in lung cancer of 35 patients with chemotherapy group and 35 patients with non-chemotherapy group.The relationship between their expression and its survival rate were analysed.Results:The positive rate of Survivin and CD105 was 74.3%and 67.1%,Survivin and CD 105 were positive correlated in the expression of lung cancer tissues?And there was a significant difference in the mid-survival time between the expression of Survivin and CD 105 in two groups,the survival time of negative expression of Survivin and CD 105 in chemotherapy group was the longest one.Conclusion:The expression of Survivin and CD 105 in lung cancer might be important marker in the effect of chemotherapy,prognosis in lung cancer.更多还原