【作者】 梁鹏； 钟进才；

【Author】 LIANG Peng ▲ ZHONG Jin-cai First Affiliated Hospital of Guangxi Medical University, hospices,Nanning, Guangxi 530021

【机构】 广西医科大学第一附属医院宁养院；

【摘要】 目的:观察能否通过吗啡向羟考酮的转换来减轻癌痛患者对阿片类药物的耐受。方法:采用前瞻性的自身对照试验设计。用(1.5:1)作为各组病人吗啡向羟考酮转换的基础比率,用NRS评分,QOL评分,KPS评分作为转换前后镇痛效果及生活质量、生活能力的评价指标。结果:各组患者吗啡/羟考酮的平均比值随着吗啡剂量的增加而增加,并且比值与吗啡的剂量呈线性趋势F=0.003、P=0.954>0.05。所有病人转换前后NRS评分、QOL评分未见明显差异(P>0.05),但KPS评分转换前较转换后高(P<0.05),两药主要不良反应有头晕,便秘,恶心,排尿困难,皮肤瘙痒等。结论:通过羟考酮转换能达到与吗啡相当的镇痛效果,并且可能是减缓吗啡耐药的新途径。更多还原

【Abstract】 OBJECTIVE: Observe whether we could reduce the resistance of opioid drug by the conversion from oral morphine to oral oxycodone in cancer patients.METHODS: A experiment design with prospective self-control.take (1.5:1) as the base conversion rate of (morphine/oxycodone) in each group patients and take the NRS score,QOL score and KPS score as the assessment indicator of analgesic effect,quality life skills and life skills before and after the conversion. RESULTS: With the increase of morphine dosage,the mean ratio of (morphine/oxycodone) growing up,moreover,the ratio and the morphine dosage showing linear trend (F = 0.003, P = 0.954>0.05). the scores of NRS and QOL of patients have no significant different before and after conversion (P >0.05), before conversion,the KPS score was higher (P <0.05), the main side effects of the two drugs are dizziness, constipation, nausea, dysuria, skin itching and so on. CONCLUSION: Through conversion, oxycodone can achieve equivalent analgesia as morphine,and it may be a new way to reduce the resistance of morphine for patients.更多还原