【作者】 邱立华； 王华庆； 钱正子； 李维； 侯芸； 孟祥睿； 崔秀珍； 郝希山；

【Author】 QIU Li-hua,WANG Hua-qing,QIAN Zheng-zi,LI Wei,HOU Yun,MENG Xiang-rui CUI Xiuzhen,HAO Xishan Tianjin Medical University affiliated Cancer Hospital,Tianjin 300060,China

【机构】 天津医科大学附属肿瘤医院淋巴瘤科乳腺癌防治教育部重点实验室；

【摘要】 目的探讨乳腺原发恶性淋巴瘤(PBL)的发病率、高发年龄、发病趋势、影像学特点、转移规律、不同治疗方法对预后的影响。方法收集1960年1月至2007年8月天津市22811例乳腺恶性肿瘤和7337例恶性淋巴瘤中49例PBL的性别、年龄、病理类型、乳腺钼靶x线、B超检查资料、转移部位及治疗、预后相关资料。结果天津市PBL的发病率为1.4/10万,高发年龄:30～59岁,发病率逐年增加,非霍奇金淋巴瘤(NHL)占绝大部分,乳腺钼靶x线、B超、冰冻检查不典型,脏器受累以骨髓、肺脏、脑膜、卵巢多见,5年生存率仅为6.12%,根治术联合化疗及放疗优于局部手术联合化疗。结论PBL是一组罕见的结外淋巴瘤,发病率逐年增加,临床及影像学表现不典型,易骨髓、肺脏、脑膜、卵巢受累,治疗方案以根治术联合化疗及局部放疗为佳,但预后不良。更多还原

【Abstract】 Objective To explore the disease incidence,clinical characteristics,diagnosis, route of metastasis,treatment and prognosis for primary breast lymphoma(PBL).Methods The clinical data of 49 cases of PBL were retrospectively analyzed.Results The disease incidence of PBL was 1.4/100,000,frequently encountered age was 30 to 59 years old,most of PBL was non-hodgkin’s lymphoma,the clinical characteristics of examination by breast x ray,B ultrasound and frozen section were atypical.Bone marrow,lung,meninges and ovary were frequently involved. The overall 5 year survival rate was 6.12%for the whole group.Radical mastectomy combined with CHOP or CHOP like regimen was super to local mastectomy together with chemotherapy. Conclusions PBL is a rare lymphoma with incidence increasing sharply.Clinical manifestation is atypical.Diagnosis of PBL should adopt histological examination.Treatment should combine radical mastectomy and chemotherapy.Even so,the prognosis is still poor.更多还原