【作者】 吕广明； 王艳杰； 刘瑞； 孙聆东； 黄云辉； 严纯华；

【Author】 Guang-Ming Lyu;Yan-Jie Wang;Rui Liu;Ling-Dong Sun;Yun-Hui Huang;Chun-Hua Yan;Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, PKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic Chemistry, College of Chemistry and Molecular Engineering, Peking University;School of Materials Science and Engineering, Huazhong University of Science and Technology;

【机构】 北京大学稀土材料化学及应用国家重点实验室； 北京大学-香港大学稀土材料和生物无机化学联合实验室； 北京大学化学与分子工程学院,北京分子科学国家实验室； 华中科技大学材料科学与工程学院；

【摘要】 糖尿病是困扰当代人健康的世界性顽疾之一,它的发生与氧化应激密切相关,机体内活性氧自由基(ROS)的过量产生和抗氧化能力的减弱是其发生和发展的重要病理机制。CeO2纳米材料中的Ce3+和Ce4+能够可逆的转化,这一性质使得纳米CeO2可以催化分解生物体内的过量ROS,对氧化应激导致的糖尿病具有潜在的治疗作用。本文利用醋酸辅助水热法合成了5 nm和25 nm的CeO2立方块,材料展现出清除H2O2,O2·-,·OH等活性氧的能力,并且其活性与材料的水合半径相关。CCK-8测试表明纳米CeO2没有对胰岛β细胞INS-1的生长和增殖造成影响,同时能保护INS-1细胞免于H2O2诱导的细胞凋亡。这些结果表明CeO2纳米材料可以成为一种潜在的抗氧化剂,对ROS造成的胰岛β细胞损伤起到保护作用。Fig.1 A.TEM and HRTEM images of CeO2 nanocubes.B.Nanoceria reduces H2O2-induced apoptosis.更多还原

【Abstract】 Diabetes is a huge threat to the health of people in modern times. Oxidative stress plays a key role in the occurrence and development of diabetes. Nanoceria is known to exhibit ROS scavenging activity by reversibly binding oxygen and shifting between the Ce3+ and Ce4+ formed at the particle surface, so nanoceria may have potential application in the cure of diabetes resulting from oxidative stress. Here, Hydrophilic ceria nanocubes have been prepared by convenient acetate assisted hydrothermal method. These nanocubes displayed catalytic reactivity for scavenging H2O2, O2·- and ·OH, and its activity associated with the hydrodynamic size of nanoparticles. CCK-8 assay revealed that nanoceria did not affect cell growth and function of INS-1 cells, while being able to protect INS-1 from H2O2-induced cytotoxicity. Therefore, these findings confirm that nanoceria can become a potential antioxidant for controlling ROS-induced pancreatic β-cell damage.更多还原