【作者】 王艳杰； 吕广明； 刘瑞； 黄云辉； 孙聆东； 严纯华；

【Author】 Yanjie Wang;Guangming Lv;Rui Liu;Yunhui Huang;Lingdong Sun;Chunhua Yan;Materials Chemistry and Applications, PKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic Chemistry, College of Chemistry and Molecular Engineering, Peking University;College of Materials Science and Engineering, HuaZhong University of Science and Technology;

【机构】 北京大学稀土材料化学及应用国家重点实验室； 北京大学-香港大学稀土材料和生物无机化学联合实验室； 北京大学化学与分子工程学院,北京分子科学国家实验室； 华中科技大学材料科学与工程学院；

【摘要】 <正>纳米CeO2因Ce3+与Ce4+可逆循环的性质在生物抗氧化领域备受关注。CeO2的抗氧化的机理的研究对其生物抗氧化应用具有重要的指导意义。本文主要在水溶液与INS-1细胞中研究了纳米CeO2与活性氧物种的作用机理。我们通过简单的水热法制备得到分散性较好的CeO2纳米材料,通过XRD、XPS、TEM、HRTEM、FTIR等测试手段对CeO2的物理化学性质进行表征,并选择H2O2作为活性氧物种的研究模型,采用紫外可见光谱、拉曼光谱、EXAFS测试原位研究了CeO2与H2O2反应过程中紫外吸收边的移动、铈配位数的变化及反更多还原

【Abstract】 Ceria attract large attention as an ideal anti-oxidant material due to the reversible conversion between Ce3+ and Ce4+. Anti-oxidation mechanism is the basis of bio-application of ceria. This work focus the mechanism how nano-ceria reacts with H2O2 in chemical solutions and anti-oxidation protection in INS-1 cells. Ceria nanocrystals with good dispersity were prepared though a simple hydrothermal method. We study the anti-oxidation mechanism of ceria by situ EXAFS, Raman Spectrum choosing H2O2 as a typical reactive oxygen species. Moreover, we improve the catalytic activity by Gd3+ dopant, and the ceria and Gd3+ doped ceria show excellent anti-oxidation protection performance in INS-1 cells during the high glucose environment.更多还原