【作者】 周树娅； 刘娜； 赵雪秋； 杨丽娟；

【Author】 Shu-Ya Zhou;Na Liu;Xue-Qiu Zhao;Li-Juan Yang;School of Chemistry and Biotechnology,Yunnan Minzu University;

【机构】 云南民族大学化学与生物技术学院；

【摘要】 巴西木素(Brazilin)系豆科植物苏木的主要活性成分,为高异黄酮类化合物的衍生物,具有抗菌、降血糖、抗肿瘤、抗血小板凝聚、免疫调节等多种生物活性[1,2]。然而,巴西木素较低的水溶性和不稳定性,限制了它在药物制剂的应用。本文对巴西木素与环糊精的主—客体体系研究。通过紫外光谱滴定法,测定了环糊精和巴西木素分子之间的化学计量比和键合常数;通过核磁共振研究了环糊精与巴西木素之间的包结行为,探讨了主客体之间的键合模型;采用粉末X-射线衍射、热分析以及扫描电镜等表征研究了固体包结物的性能。结果显示:形成超分子体系后,巴西木素分子的水溶性、稳定性及生物利用度均明显提高。更多还原

【Abstract】 The inclusion complexation behavior, characterization and binding ability of brazilin with β-cyclodextrin(β-CD) and its derivative 2-hydroxypropyl-β-cyclodextrin(HPβCD) were investigated in both solution and the solid state by means of XRD, DSC, SEM, 1H and 2D NMR and UV–vis spectroscopy. The results showed that the water solubility and thermal stability of brazilin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high stability of the brazilin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products.更多还原