【作者】 刘亚静； 莫洪昌； 丁峰； 高福磊； 姬月萍；

【Author】 LIU Ya-jing,MO Hong-chang,DING Feng,GAO Fu-lei,JI Yue-ping (Xi’an Modern Chemistry Research Institute,Xi’an 710065,China)

【机构】 西安近代化学研究所；

【摘要】 以丙三醇为原料,经酯化、叠氮化两步反应合成出甘油三叠氮乙酸酯(GTAA),总收率为84.1%;利用红外光谱、核磁共振、元素分析等手段对中间体与目标化合物的结构进行表征,探讨了酯化反应及叠氮化反应的影响因素。叠氮化反应的最佳条件:NaN3摩尔量为理论值的1.1倍,混合溶剂中水占总体积的5%～25%,反应时间10h,收率95.0%,纯度不小于96.8%(HPLC)。更多还原

【Abstract】 Glycerol tris（azidoacetin） was synthesized using propanetriol as raw materials,via two-step reactions of esterification,azidonation,and the overall yield was 84.1%.The structures of target compound and intermediates were characterized by IR,NMR and elemental analysis.The affecting factors of reactions were optimized.The optimum reaction conditions of azidonation were:molar ratio n_exp:n_theory=1.1 for NaN₃,the mixed solvent ratio of acetong-H₂0 were 5%-25%and reaction time 10h. The yield of TAA is about 95.0%and purity 98.5%.更多还原