【作者】 林瑜； 韦小玲； 龚琦； 王立升；

【Author】 LIN Yu,WEI Xiao-ling *,Gong Qi,WANG Li-sheng College of Chemistry and Chemical Engineering,Guangxi University,Nanning 530004

【机构】 广西大学化学化工学院；

【摘要】 本文根据羧甲司坦分子结构特征,推测其分子应该具有与金属离子络合的条件。通过紫外可见分光光度法考察了羧甲司坦与各种金属离子络合的可能性。经研究发现羧甲司坦分子与Cu2+可以形成稳定络合物,该络合物在237nm处有一个最大特征吸收峰。研究了介质、酸度、反应温度和时间等因素对羧甲司坦和金属离子形成络合物的影响,并确定该络合物形成的最佳条件。本文还对Cu2+-羧甲司坦络合反应的机理进行了初步探讨,确定了的络合物的络合比羧甲司坦:Cu2+为2:1,络合物稳定常数为4.98×109,在237nm处络合物的摩尔吸光系数最大为4.74×103L.mol-1.cm-1。建立了基于Cu2+络合的紫外分光光度法定量测定羧甲司坦的新方法。该方法简单、快速、灵敏且成功应用于不同药厂的产品分析,结果与标示量相符,回收试验回收率为96.84-103.1%之间,测定RSD为2.16%。更多还原

【Abstract】 Based on Carbocisteine molecular structure,the paper suggest that the molecule should have the conditions for metal ions.By violet-visible spectrophotometry outside carbocisteine the research investigated the various metal ions possibilities.The study found that carbocisteine molecules and Cu 2+ can form a stable complex.The complex has a maximum at the characteristic absorption peak of 237 nm.Studied the medium acidity,reaction temperature and time on the Carbocisteine and metal ions form complexes influence and determine the best conditions for the complex formation.Cu 2+-Carbocisteine complexation reaction mechanism was discussed to determine the complexation complex that the rate between carbocisteine and Cu 2+ is 2:1,complex stability constant is 4.98×10 9,the complex molar absorption coefficient at 237nm is 4.74×10 3 L.mol-1.cm-1.Based on Cu 2+ complexed quantitatively determined by UV spectrophotometry,the research establish a new method.The method is simple,rapid,sensitive and successfully applied to the analysis of various pharmaceutical products,results consistent with the labeled amount,recovery test recoveries were from 96.84% to 103.1%,the RSD was 2.16%.更多还原