【作者】 杨鑫； 林滢滢； 李静； 刘岚；

【Author】 Yang Xin 1,Lin Yingying 2,Li Jing 3*,Liu Lan 3* 1.Department of Chemistry,College of Life Science and Technology,Jinan University,Guangzhou 510632,China 2.School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China 3.School of Marine Sciences,Sun Yat-sen University,Guangzhou 510006,China

【机构】 暨南大学生命科学技术学院化学系； 中山大学化学与化学工程学院； 中山大学海洋学院；

【摘要】 目的对南海红树林内生真菌Penicillium sclerotiorum SP.303次级代谢产物进行研究。方法采用各种色谱技术对次级代谢产物进行分离纯化,然后根据化合物的理化性质及光谱数据鉴定化合物的结构。结果从南海红树林内生真菌Penicillium sclerotiorum SP.303次级代谢产物中分离并鉴定了6个azaphilone类化合物,分别为:6-(3,5-dimethyl-1,3-heptadien-1-yl)-2,4-dihydroxy-3-methyl-benzaldehyde(1)、sclerotiorin(2)、sclerotioramine(3)、isochromophilone VI(4)、dimeric isochromophilone(5)、isochromophiloneⅨ(6)。结论化合物1、5是首次从天然产物中分离得到。更多还原

【Abstract】 Objective:study on the secondary metabolites of mangrove endophytic fungus Penicillium sclerotiorum SP.303.Methods:The compounds were isolated by chromato0graphic technique.The structures were elucidated through physicochemical and spectral data.Results:Six metabolites were obtained and elucidated as 6-(3,5-dimethyl-1,3-heptadien-1-yl)-2,4-dihydroxy-3-methyl-benzaldehyde(1)、sclerotiorin(2)、sclerotioramine(3)、isochromophilone VI(4)、dimeric isochromophilone(5)、isochromophilone Ⅸ(6).Conclusion:Compounds 1、5 were isolated from natural products for the first time.更多还原