【作者】 王路； 张思琪； 吴江； 周百斌；

【Author】 Lu Wang 1,2 , Si-Qi Zhang 2 , Wu Jiang 1 , Bai-Bin Zhou 1,* 1 Harbin Normal University, Harbin, Heilongjiang 150025 2 Harbin Institute of Technology, Harbin, Heilongjiang 150090

【机构】 哈尔滨师范大学； 哈尔滨工业大学；

【摘要】 <正>本文合成了含有磺胺配体的Keggin型多金属氧酸盐[{K(C6H10N2O2S)2(H2O)}2(SiW12O40)2]·2H3O+·10H2O(1),并通过元素分析、IR、TG、XPS、183WNMR和单晶X-射线衍射表征其晶体结构。体外实验研究了化合物1的抗肿瘤活性,结果表明,化合物1较配体[σ-SiW12O40]4-和黄胺具有较高的抗肿瘤生物学活性,尤其对人肝癌HepG-2细胞,细胞形态学研究也表明化合物1可诱导癌细胞凋亡,因此,化合物1可成为人类更多还原

【Abstract】 Abstract One new Keggin-type polyoxometalates with the ligand of sulfasulfonamide, [{K(C6H10N2O2S)2(H2O)}2(SiW12O40)2]·2H3O+·10H2O(1), has been synthesized. The structure of 1 was analyzed by elemental analysis, IR, TG, XPS, 183 WNMR, and single crystal X-ray diffraction. To evaluate the anti-tumor inhibitory effect of 1 on human cancer lines, in vitro studies were carried out. The results showed that 1 has much higher activities than its parent ligands units [_σ-SiW12O40]4- and sulfasulfonamide, especially with growth inhibitory effect against human liver cancer HepG-2 cells. The cell morphology changes showed that 1 induced apoptosis of tumor cells. Thus, our findings indicated 1 as a potential, new chemopreventive drug for human malignant tumour. Other detailed anti-tumor biological activities also will be studied in follow-up experiments in vitro and in vivo.更多还原