【作者】 段玉； 李银辉； 李继山； 杨荣华；

【Author】 Yu Duan,Yinhui Li,Jishan Li,Ronghua Yang State Key Lab of Chemo/Biosensing and Chemometrics,Hunan University,Changsha,410082

【机构】 湖南大学化学化工学院化学生物传感与计量学国家重点实验室；

【摘要】 <正>近年来,大量的有机探针被设计和合成并用于检测生物硫,但是大部分探针对半胱氨酸,高半胱氨酸以及谷胱甘肽并没有选择性,1目前,能对这三种生物硫进行选择性检测分子探针却鲜有报道。2本研究设更多还原

【Abstract】 Despite considerable efforts have been devoted to design of various chemsensors for biological thiols,they do not possess good selectivity toward Cys,Hcy and GSH.Here,we design and synthesize a colorimetric probe based on the spirocylic signal to detect Cys selectively.The probe contains an active site(dinitrobezenesulfonyl group) and a chromophore(merocyanine).In the present of Cys,the dinitrobezenesulfonyl group can be removed by a well-known thiol-mediated cleavage by an SNAr process,liberating the merocyanine chromophore which converts to its spiropyran form accompanying with the characteristic absorption(λabs=360 nm).Howere,In the present of Hcy and GSH,the the characteristic absorbance at 360nm can not be seen.更多还原