【作者】 许华平； 马宁； 张希；

【Author】 Xu Hua-ping,Ma Ning,Zhang Xi Department of Chemistry,Tsinghua University,Beijing 100084

【机构】 清华大学化学系；

【摘要】 <正>刺激响应高分子材料可以用于药物传输与释放等。由于C-Se键和Se-Se键键能比较低,键比较活泼,使得含硒高分子成为一类特殊的刺激响应材料,具有许多独特和优异的性质。更多还原

【Abstract】 Redox responsive polymers have attracted wide interest for their promising applications in controllable encapsulation and delivery in physiological environments, where the redox process is constantly and widely present.Selenium-containing compounds have been widely used in the pharmacochemistry as antioxidants for the well-known glutathione peroxidase(GPx) activity,among which diselenide is a promising candidate for a dual redox response due to its good activity in the presence of either oxidants or reductants.It is fully expected that this kind of selenium-containing multiresponsive block copolymer aggregate may function as a controlled drug delivery system,enabling a combination of chemotherapeutics and actinotherapy.更多还原