【作者】 易健民； 杨长安； 唐课文； 索会峰；

【Author】 YI,Jian-Min,YANG,Chang-An~*,TANG,Ke-Wen,SUO,Hui-Feng (Department of chemistry and chemical Engineering,Hunan Institute of Science and Technology,Yueyang 414000)

【机构】 湖南理工学院化学化工学院；

【摘要】 在水相和有机相中分别加入疏水性酒石酸酯和水溶性环糊精衍生物构成双相(W/O)识别手性萃取体系,首次用于第一菊酸对映体的手性分离,研究了水相萃取剂手性识别能力和识别方向,考察了L-酒石酸酯浓度、羟丙基-β-环糊精的浓度、L-酒石酸酯烷基链长度、水相pH和甲醇水溶液浓度等因素对分配系数k和分离因子α的影响。研究表明:L-酒石酸酯和HP-β-CD的手性识别方向是一致的,识别分离能力是相互增强的,分离因子α值可由单相识别时的1.30提高到1.70。更多还原

【Abstract】 Biphasic recognition chiral extraction system has been constructed,in which two kinds of extractant with opposite recognition direction(hydrophobic D-/L-tartaric acid esters and water-soluble cyclodextrin derivatives) are added in the organic phase and water phase, respectively.This system is used to separate two kinds of chrysanthemic acid enantiomers. P-CD derivatives have stronger recognition abilities for S-chrysanthemic acid than those for R-chrysanthemic acid,while L-tartrate derivatives have reversed recognition abilities.Thus the use of appropriate two-phase chiral extractant greatly enhances separation ability.Adding HP-β-CD,the separation factor value can be enhanced from 1.30 for the single-phase to 1.70 for two-phase extraction.Furthermore,the effects of the concentrations of L-tartaric acid esters and HP-p-CD,length of alkyl chain of tartaric esters,pH and the concentrations of aqueous methanol solution on the partition coefficients(k) and separation factors(α) are examined.更多还原