【作者】 陈求扬； 郑金凤； 梁庆福； 林淑芳； 赵永； 魏淑贞； 林建；

【Author】 Chen Qiuyang,Zheng Jinfeng,Liang Qingfu,Liu Shufang,Zhao Yong,Wei Shuzhen,Lin Jin (Fujian Center for Disease Control and Prevention,Fuzhou 350001,China)

【机构】 福建省疾病预防控制中心；

【摘要】 目的了解福建省结核病耐药基本状况,为制定结核病控制对策提供依据。方法 2008年9月至2009年8月,在9个设区市随机各抽查1个县结核病门诊新登记涂阳患者,采用WHO/IUA TLD推荐的比例法对分离的结核分枝杆菌复合群进行H、R、S和E耐药性检测。结果 1014例患者总体耐药率19.8%,耐多药率4.6%。其中初始耐药率17.9%,初始耐多药率3.4%;获得性耐药率44.0%,获得性耐多药率20.0%。结论福建省9个调查点结核病耐药率处于较低水平,今后要加强青壮年患者的全程督导管理和H、S的合理用药。更多还原

【Abstract】 Objective To understand the situation of drug resistant tuberculosis in Fujian province,and aim to provide evidence to formulate policy of TB control.Methods All new registered sputum smear-positive patients in 9 surveillance sites in Fujian province were collected from September 2008 to August 2009.All culture positive sample were conducted identification and the MTB strains were used proportion method recommended by WHO/the UNION in drug susceptibility test for isonizid,rifampicin,streptomycin and ethambutol.Results The total drug resistance rate of 1014 cases investigated in surveillance sites was 19.8%and total multi-drug resistance(MDR) rate was 4.6%.The initial DR rate was 17.9%and initial MDR rate was 3.4%.The acquired DR rate was 44.0%and acquired MDR rate was 20.0%.Conclusion The drug resistant rate of tuberculosis in 9 surveillance sites in Fujian was low compared to the national average level.We must strengthen full-course supervision and treatment and management for the young cases.更多还原