【作者】 杨卫丽； 赖伟勇； 张俊清； 刘明生；

【Author】 YANG Wei-Li,LAI Wei-Yong,ZHANG Jun-Qing,LIU ming-sheng~([27]) (Hainan Medical College,Hainan Provincial Key Laboratory of R & D of Tropical Herbs Hainan Haikou 571101)

【机构】 海南医学院药学系海南省热带药用植物研究开发重点实验室；

【摘要】 目的观察胆木不同提取部位的急性毒性。方法以最大浓度及最大给药体积的药液灌胃给药,3次/d。连续观察7d,记录小鼠毒副反应情况。结果观察7d后,全部动物健存,小鼠体重平均增长28.14%和21.46%,均未见任何毒性反应。胆木水提物最大给药量为400g/kg体重,相当于成人日用量的200倍;胆木总生物碱给药量为24g/kg。结论胆木不同提取部位毒性均较小。更多还原

【Abstract】 Objective To study the acute toxicity of different extractions of Nauclea officinalis (DEONO).Methods The maximum administration dosage of DEONO were determined by ig administration in mice,and three times a day.Its acute toxic reactions were observed for 7 days.Results All mice were survive,and no toxic reaction was shown during the observed period.The average rate of increasing weight of water extract and total alkloids were 28.1% and 21.47%,respectively.The maximum administration dosage(400g/Kg) of water extract was equal to 200 times of men’s daily administration dosage and the maximum administration dosage of total alkloids was 24g/Kg.Conclusion The DEONO were safe for oral administration.更多还原