【作者】 艾均文； 孟繁利； 贾孟周； 李章宝； 何行健； 朱勇； 向仲怀；

【Author】 Ai Jun-Wen1,2 Meng Fan-Li1 Jia Meng-Zhou1 Li Zhang-Bao1 He Xing-Jian1 Zhu Yong2 Xiang Zhong-Huai3 (1 The Sericultural Research Institute of Hunan Province,Changsha 410127,China;2 College of Biotechnology,Southwest University,Chongqing 400716,China;3 The Key Sericultural Laboratory of Agricultural Ministry,Chongqing 400716,China)

【机构】 湖南省蚕桑科学研究所； 西南大学生命技术学院； 西南大学农业部蚕桑重点开放实验室；

【摘要】 细胞色素P450是一种广泛存在于所有需氧生物体中的一类代谢酶,在生命的过程中,它对内源物质的代谢与转化或外源化合物的活化与降解等进行催化和调控。昆虫是地球上最繁盛的生物种群,P450的作用涉及昆虫生长、发育、取食等过程,它对异生物质的代谢特性导致了昆虫对杀虫剂的抗药性和对植物有毒物质的耐受性,它还参与了昆虫体内许多内源化合物的合成与代谢。本文简要介绍了昆虫P450分子的基本特征,综述了它对蜕皮激素、保幼激素、植物次生物质及杀虫剂合成与降解等方面作用,阐述了基因组学在昆虫P450基因研究方面的应用与进展。更多还原

【Abstract】 Cytochrome P450 enzymes are a complex family of heme-containing enzymes found in virtually all aerobic organisms.Many functions are attributed to cytochrome P450s including the metabolism of a wide variety of both endogenous substrates and xenobiotics.Insects are the most prosperous life form on the planet with wide distribution.Insect P450s catalyze the metabolism of physiologically important endogenous compounds but are best known for their roles in the detoxification of plant allelochemicals and insecticides.In this mimi-review article,we summarized the molecular characteristics of insect P450,and their functions involved in the biosynthetic and metabolic pathways of ecdysteroids and juvenile hormones,detoxifications of plant allelochemicals,metabolic resistance to insecticides,and reasearch advances and prospects of insect P450 genomics.更多还原