Intermittent exposure of quiescent chronic myeloid leukemic stem cells to G-CSF in vitro promotes their elimination by imatinib mesylate

【作者】 房佰俊； 宋永平； 魏旭东； 张丽； 李玉富； 符粤文； 林全德； 周健； 喻凤宽； 马慧珍；

【Author】 Baijun Fang Yongping Song Xudong Wei Gongli Zhang Yufu Li Yuewen Fu Quande Lin Jian Zhou Fengkuan Yu Huizhen Ma Henan Tumor Hospital,Henan Institute of Hematology Zhengzhou 45008

【机构】 Henan Tumor Hospital,Henan Institute of Hematology；

【摘要】 <正>Background & Objective:Primitive quiescent chronic myeloid leukemia(CML) cells are biologically resistant to imatinib mesylate,an inhibitor of the p210(BCR-ABL) kinase.The present study was designed to investigate whether either continuous or intermittent exposure of these cells to granulocyte-colony-stimulating factor(G-CSF) in vitro can更多还原