新型激光衍射粒径测定在吸入气雾剂开发和评价中的应用研究

【作者】 张熹； 金方；

【机构】 上海医药工业研究院,上海呼吸系统药物工程技术研究中心；

【摘要】 目的研究激光衍射粒径测定在表征吸入气雾剂体外粒径分布中的应用。方法应用激光衍射粒径测定不同气雾剂的体外粒径分布,并与惯性碰撞法的结果比较。结果测定结果与惯性碰撞法接近,能够有效测定初始雾滴并反应大雾滴的粒径变化。结论在吸入气雾剂体外粒径测定中,激光粒径测定能够补充并一定程度上替代惯性碰撞沉积法,加快处方筛选和评价,促进对气雾剂给药原理的研究。更多还原

【Abstract】 Target To study the application of laser diffraction sizing in characterizing inhaled aerosol in vitro,as an alternative and supplement to inertial impaction test.Method To characterize size distribution of different samples,and compare the results with inertial impaction method.Result The laser diffraction results were similar to inertial impaction and effectively reflect the size change of large droplets.Conclusion Laser diffraction sizing method could supplement and somewhat replace inertial impaction test.更多还原