【作者】 彭新生； 周艳芳； 韩珂； 覃玲珍； 吴传斌；

【Author】 PENG Xinsheng 1,2,Zhou Yanfang 1,HAN Ke 3,QIN Linzhen 2,WU Chuanbin2 (1.School of Pharmaceutical Sciences,Guangdong Medical College,DongGuan 523808,China;2.School of Pharmaceutical Sciences,Sun Yat-Sen University,GuangZhou 510006,China;3.The Second Affiliated Hospital of Guangzhou Medical College,Guangzhou 510260,China)

【机构】 广东医学院药学院； 中山大学药学院； 广州医学院第二附属医院；

【摘要】 目的探讨立方液晶纳米粒包裹的辣椒碱在体外透皮吸收能力。方法采用改良的Franz扩散池体外透皮实验技术,对辣椒碱立方液晶纳米粒及其软膏剂进行体外透皮扩散实验。结果立方液晶纳米粒制剂相对于辣椒碱软膏剂而言,无促进药物渗透作用。但立方液晶纳米粒制剂中的辣椒碱在角质层及活性皮肤中的滞留量明显高于软膏剂(P<0.01),表明立方液晶纳米粒皮肤靶向性能好。结论立方液晶纳米粒作为皮肤局部给药的载体提高作用部位的有效药物浓度,皮肤靶向性好。更多还原

【Abstract】 Objective To investigate the permeability and absorbability of capsaicin cubosome across the SD rats abdominal skin in vitro.Method Diffusion of capsaicin cubosome and cream through the rat skin was performed with the modified Franz diffusion cell technique.Results The capsaicin cubosome showed no enhancement of skin permeation within 24 hours.However,the deposition amounts of capsaicin in the rat skin in the cubosome group was markedly higher than those in the commercial capsaicin group(p<0.01).Conclusions Cubosome could enhance the drug deposition in the skin and showed excellent characetristic of skin-targed.Cubosome could be a good carrier for the transdermal drug delivery system.更多还原