【作者】 刘扬； 王玉婷； 张学农；

【Author】 LIU Yang,WANG Yu-ting,ZHANG Xue-nong (College of Pharmaceutical Science,Soochow University;Jiangsu Suzhou 215123,China)

【机构】 苏州大学医学部药学院；

【摘要】 目的以去甲斑蝥素为模型药物制备膜控型缓释微丸,并对其体外释药情况进行研究。方法采用流化床包衣法对去甲斑蝥素微丸进行缓释包衣,确定最佳机器参数,通过均匀设计优化包衣液处方。并对最佳处方进行重现和释放曲线数据拟合。结果通过U7(74)均匀设计试验,4因素7水平,得出最佳包衣液处方配比:增塑剂24%,致孔剂14%,抗粘剂20%,抗静电剂0.060%。最佳处方曲线拟合Ritger-Peppas方程。结论以EC为主要包衣材料,HPMC为致孔剂制得的缓释包衣微丸,释放缓慢,服从Fick扩散。更多还原

【Abstract】 Objective:To prepare membrane Controlled release pellets using Norcantharidin as model drug and investigate the mechanism.Methods:A fluid bed spray processor was adopted for coating the pellets of NCTD.Determine the best parameter of machines.The best coating solution was optimized with homogeneous design.The best results were repeated and the data of release curve was fitted.Results:Using U 7 (7 4)homogeneous design,which has 4 factors and 7levels,to determine the best coating solution prescription:24%plasticizer,14% porogenic agent,20% antisticking agent,0.060% antistatic agent.The best coating solution prescription fit Ritger-Peppas equation.Conclusion:Drug diffusion from the sustained-release pellets which use EC as main coating material,HPMC as porogenic agent released slowly,is Fick diffusion.更多还原