【作者】 黎小妍； 张平； 曲彩虹； 谢志忠；

【机构】 中山大学附属三院； 南华大学药物药理研究所；

【摘要】 目的比较阿托伐他汀与辛伐他汀片治疗抑郁症的成本与效果。方法将110例确诊为冠心病,血清总胆固醇TC>5.2mmol/L(200mg/L)或LDL-C>3.12mmol/L(120mg/L)或合并TG>117mmol/L(150mg/L)的患者,随机分成两组:A组57例口服阿托伐他汀片(商品名:立普妥)20mg/d;B组53例口服辛伐他汀片(商品名:舒降之),40mg/d,两组同治疗8周。于服药前、服药后第4、8周分别测定甘油三酯(TG)、血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)等指标。利用药物经济学的原理,采用成本-效果分析方法对阿托伐他汀与辛伐他汀治疗冠心病高脂血症的疗效进行评价。结果阿托伐他汀和辛伐他汀的成本分别为572.00元和552.55元,成本效果比分别为6.04和5.98。结论辛伐他汀片是调节脂质的较佳方案。更多还原

【Abstract】 To compare the cost-effectiveness of Atorvastatin Tablets and Simvastatin on Lipid Efficacy. Method 110 patients diagnosed with coronary heart disease, serum total cholesterol TC>5.2mmol/L(200mg/L) or LDL-C>3.12mmol/L(120mg/L) or merger TG>117mmol/L (150mg/L).The patients were randomly divided into two groups:A(atorvastatin tablets group) of 57 cases were given oral atorvastatin 20mg/d; B(simvastatin tablets group) of 53 cases were given simvastatin, 40mg/d, with two groups of eight weeks. In the medication before taking the first eight weeks were measured triglyceride (TG), serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and other indicators. Using the principle of pharmacoeconomics, cost-effectiveness analysis (CEA) method was carried out to assess for the atorvastatin tablets and and simvastatin tablets on lipid efficacy. Results At the end of the treatment, the costs were 572.00 yuan in atorvastatin tablets group and 552.55 yuan in simvastatin tablets group. The cost-effectiveness was 6.04 and 5.98 respectively. Conclusion Simvastatin tablets was better choice for the treatment of hyper lipidemia..更多还原