【作者】 刘继华； 刘金平； 李平亚； 卢丹；

【Author】 Liu Ji-hua,Liu Jin-ping,Li Ping-ya,Lu Dan (1 Pharmaceutical Academy of Jilin University,Changchun 130021)

【机构】 吉林大学药学院；

【摘要】 目的:对人参皂苷Rh2进行结构修饰,合成其氨基酸衍生物。方法:采用DCC缩合法,通过酯化反应将氨基酸连接在葡萄糖侧链上。结果:合成人参皂苷Rh2的氨基酸衍生物10个,利用1H-NMR和13C-NMR对其结构进行确证。结论:合成的衍生物均为新化合物,氨基酸连接在葡萄糖侧链上,糖链的C-6位是优势连接位置。更多还原

【Abstract】 OBJECTIVE The chemical structure of Ginsenoside Rh2 were modified, and the amino acids derivates were synthesized. METHODS Amino Acids were connected with hydroxyls of glucose chain by the DDC promotion and esterificaition. RESULTS Ten derivates were synthesized and their chemical structures were identified with 13 C-NMR and 1 H-NMR. CONCLUTION Ten derivates are all new compounds with amino acids in the site of glucose chain C-6.更多还原