【作者】 钟铮； 武雪芬； 杨静； 高巍； 王新灵； 田圣志；

【Author】 Zheng Zhong,Xue-Fen Wu,Jing Yang,Wei Gao,Xin-Ling Wang and Sheng-Zhi Tian Henan University of Traditional Chinese Medicine,Zhengzhou 450008

【机构】 河南中医学院；

【摘要】 乙型肝炎是严重威胁我国广大人民的传染性疾病。乙型肝炎是由乙肝病毒(HBV)感染引起的。核苷抑制剂是抗乙肝病毒治疗的主要途径。以RNA依赖的RNA聚合酶为靶点,我们以D-木糖为起始原料合成了氟取代嘌呤核糖核苷化合物1,该路线简单,收率较好,能够满足合成大量类似物的药物化学研究需要。更多还原

【Abstract】 Chronic hepatitis B is one of the most severe infectious diseases in china which is caused by Hepatitis B virus infection. Nucleoside inhibitors have been showed the effectiveness towards hepatitis B virus infection. Targeted to the RNA-dependent RNA polymerase we synthesized the fluoro-purine ribonucleoside 1. This synthetic route is facile for synthesis of its analogues because of its short and practical rout with moderate yield.更多还原