【作者】 温航远； 杨新波； 黄正明； 陈红艳； 耿淼； 王建华； 苏成虎；

【机构】 解放军总医院老年医学研究所； 北京化工大学； 解放军302医院药学部；

【摘要】 目的研究复方连芪消渴胶囊(lianqi xiaoke capsule,LXC)对糖尿病肾病大鼠的作用。方法采用高糖高脂饲料配合低剂量链脲佐菌素(streptozotocin,STZ;30mg/kg)方法诱导糖尿病大鼠模型。将成模大鼠分组为模型组、LXC治疗(2,4,8g·kg-1·d-1)组、盐酸二甲双胍组(0.2g·kg-1·d-1),治疗8周各组大鼠进行空腹血糖、肾功能相关检测以及病理组织学观察肾脏。结果①与正常组对比,模型组空腹血糖、肾指数、尿量、微量白蛋白(mAlb)、血肌酐(SCr)、尿素氮(BUN)出现明显升高;超氧化物歧化酶(SOD)水平降低而丙二醛(MDA)水平升高。光镜下观察肾小球及基底膜增生,肾小球细胞数增多。②与模型组对比,LXC治疗(4,8g·kg-1·d-1)组空腹血糖、肾指数、尿量、mAlb、SCr、BUN明显降低,肾组织结构异常变化得到改善,肾组织SOD水平升高和MDA水平降低;③与模型组对比,盐酸二甲双胍组空腹血糖明显降低,尿量明显较少,肾脏SOD水平升高。讨论连芪消渴胶囊具有降低空腹血糖和保护糖尿病早期肾病的作用,降低氧化应激水平可能是其治疗机制之一。更多还原

【Abstract】 Aim to investigate the renoprotective effect of LXC in diabetic rats. Method Diabetic rats model were induced with high sucrose-fat diet and streptozotocin(STZ, 30mg/kg). Diabetic rats were randomly grouped into model group, LXC treatment groups(2, 4, 8g·kg-1·d-1), and MHT group(0.2g·kg-1·d-1). After 8 weeks` administration, the level of fasting blood glucose, renal function indices and pathological changes were observed. Result ① model group vs normal control group: fasting blood glucose, kidney index, urine volume, mAlb, SCr, BUN decreased significantly, renal structure damage appeared, SOD decreased and MDA increased. ② LXC treatment groups vs model group, the fasting blood glucose, kidney index, urine volume, mAlb, SCr, BUN decreased significantly, kidney structure damage ameliorated, the level of SOD increased and MDA decreased. ③ MHT group vs model group: the high level of fasting blood glucose and urine volume obviously decreased, the level of SOD increased. Conclusion: Our data suggested that LXC treatment ameliorated fasting blood glucose, and diabetic nephropathy via the inhibition of oxidative stress.更多还原