【作者】 张彬锋； 侴桂新； 王峥涛；

【Author】 ZHANG Bin-Feng~a)~b),CHOU Gui-Xin~(*a))~b) and WANG Zheng-Tao~(*a))~b) (a)Key Laboratory of Standardization of Chinese Medicines,Ministry of Education,Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine,Cai Lun Road 1200,Zhangjiang,Shanghai,201203,China;b)Shanghai R&D Center for Standardization of Chinese Medicines,Shanghai 201203,China)

【机构】 上海中医药大学中药研究所中药标准化教育部重点实验室； 上海中药标准化研究中心；

【摘要】 目的对马钱科(Loganiaceae)钩吻(Gelsemium elegans)茎的生物碱类化学成分进行研究。方法采用不同柱色谱技术进行分离,通过波谱分析和X-Ray衍射等方法确定化合物结构。结果分离鉴定了8个吲哚型生物碱,分别鉴定为11,14-dihydroxygelsenicine(1),11-hydroxygelsenicine(2),钩吻素子(koumine,3),钩吻碱(gelsemine,4),胡蔓藤碱丙(humantenmine,14-hydroxygelsenicine,5),11-hydroxyhumantenine(6),钩吻素己(gelsenicine,7),和19-(Z)-Akuammidine(8)。结论:化合物1,2为两个新的吲哚型生物碱,其中化合物1的结构经X-Ray单晶衍射得到了确证。更多还原

【Abstract】 OBJECTIVE To study the alkaloids from the stems of Gelsemium elegans.METHODS The alkaloids were isolated and purified by column chromatography and identified by spectroscopic and X-Ray analysis.RESULTS 8 Indole alkaloids were isolated from the 95%EtOH extract of the stems of G.elegans and their structures were identified as 11, 14-dihydroxygelsenicine(1),11-hydroxygelsenicine(2),koumine(3),gelsemine(4),humantenmine(or 14-hydroxygelsenicine) (5),11-hydroxyhumantenine(6),gelsenicine(7),and 19-(Z)-Akuammidine(8).CONCLUSION Compounds 1 and 2 were new indole alkaloids.Of these,the configuration of 1 was confirmed by X-ray diffraction analysis.更多还原