【作者】 汪洋； 宋新文； 梅艳；

【Author】 The Children’s Hospital of Wuhan,China,WANG Yang,SONG Xin-wen,MEI Yan

【机构】 武汉市儿童医院；

【摘要】 目的:探讨癫痫患儿卡马西平血药浓度与临床疗效、给药剂量、性别、年龄和体质量的相关性。方法:回顾性查阅我院临床药学室158例次癫痫患儿卡马西平血药浓度监测记录,将浓度值、性别、年龄等资料录入数据库,利用SPSS 13.0软件进行分析处理。结果:癫痫患儿卡马西平血药浓度值与性别不存在明显的相关性,但与临床疗效、给药剂量、年龄和体质量密切相关。结论:卡马西平在患儿体内的代谢过程存在一定的个体差异性,应根据每位患儿自身的具体情况并结合血药浓度监测结果来制订个体化给药方案。更多还原

【Abstract】 Objective:To approach the correlations of carbamazepine concentration in serum with clinical therapeutic effect,dosage,sex,age and body weight in epileptic children.Methods:Our clinical pharmacy room’s 158 cases/times monitoring records of serum carbamazepine concentration in children with epilepsy were consulted retrospectively and data as concentration,sex,age etc were put into data base,which were analyzed and treated by SPSS(13.0) software.Results:No significant correlation was noted between serum carbamazepine concentration in epileptic children and sex,however it was closely correlated with therapeutic effect,dosage,age and body weight.Conclusions:The individual difference in the metabolic processes of carbamazepine within an individual patient was obvious,so it’s necessary to made individualized remedy according to patients’ specific condition.更多还原