医院真菌感染危险因素的病例对照研究

【作者】 王莉； 曾伟英； 萧国穗； 王宏；

【机构】 武汉大学人民医院院感科； 中山大学附属中山医院；

【摘要】 <正>目的探索该院医院真菌感染的危险因素,为合理地制订医院感染控制措施提供依据。方法医院真菌感染危险因素研究采用1:1病例对照的研究方法,用Excel 2003建立病例和对照的资料数据库,核查无误后进行统计分析。采用SPSS12.0软件包对数据进行单因素条件Logistic回归分析,计算各研究变量的OR值及其95%可信区间,再用逐步回归法将筛选出的各因素引入条更多还原

【Abstract】 Objective To investigate the risk factors of nosocomial fungal infection on the Affiliated Zhongshan Hospital,Sun Yat-Sen University. Methods A 1:1 matched case-control study was carried out on the Affiliated Zhongshan Hospital,Sun Yat-Sen University.Data of nosocomial fungal infection were analyzed by statistical techniques of Chi-square test and conditional logistic regression. Results In the multiple conditional logistic regression model,aging(≥55 years)(OR 2.116,95%CI 1.020～4.389),total length of stay(≥4W)(OR 2.253,95%CI 1.214～4.180),arterial and venous cannula (OR3.643,95%CI 1.785～7.436),fundamental diseases(OR2.735,95%CI 1.332～5.615 1.911,95%CI 1.377～2.652) and antibiotic combination(OR7.143,95%CI 3.239～15.754) were significantly associated with increased risk of nosocomial fungal infection in all departments. Conclusion Nosocomial fungal infection is a disease with multiple risk factors,its risk factors mainly include two aspects:the factors of patients themselves and the factors related to medical treatments. In this study,we find that the two aspects are connected with the emergence of fungal nosocomial infection in different degree.We should adopt corresponding measures to prevent nosocomial infection.更多还原