【作者】 向蓉； 要林青； 闵光宁；

【Author】 Xiang Rong1,Yao Lingqing1,Wu Xinan2,Min Guangning2(1.Department of Pharmacy,the Second People’s Hospital of Gansu Province;2.Department of Pharmacy,the First Hospital of Lanzhou University,Lanzhou 730000, China)

【机构】 兰州大学第一医院药剂科； 甘肃省第二人民医院药剂科；

【摘要】 目的为1例粘液型铜绿假单胞菌感染的患者制定抗感染治疗方案。方法根据患者的具体情况,提出所需解决的临床问题,全面检索Cochrane图书馆、PubMed数据库、中国期刊全文数据库和万方数据库,查找大环内酯类应用于粘液型铜绿假单胞菌感染的相关系统评价、Meta分析、临床随机对照试验,并对所获证据进行质量评价,进而将最佳证据应用于临床实践。结果低剂量阿奇霉素与抗铜绿假单胞菌抗菌药物联用可清除曾经受到生物膜保护的致病菌。将以上证据结合患者意愿应用于该患者后效果良好。结论应用循证医学的方法为患者制定合理的治疗方案,可以提高患者治疗效果。按照意愿更多还原

【Abstract】 OBJECTIVE:To formulate an evidence-Based treatment plan for a patient with bronchiectasis infected the mucoid pseudomonas aeruginosa. METHODS A search was conducted in the Cochrane Library,PubMed,CNKI and Wanfang Data to obtain and evaluate the relevant systematic reviews, meta-analysis and randomized controlled and finally to apply the best evidence in clinical practice.RESULTS The pathogens once protected by the biofilm can be cleared when the low dose of azithromycin associated with anti-Pseudomonas aeruginosa antimicrobial agents.The results is good after the the plan is applied to the patient.CONCLUIONS To formulate an evidence-Based treament plan can improve the patient curative effect.更多还原