抗菌药物引起的凝血障碍原因探讨

【作者】 刘萍； 司继刚；

【机构】 淄博市中心医院临床药学科；

【摘要】 药物引起凝血障碍已为医源性疾病中重要症征之一。部分抗菌药物可引起明显的血小板减少或血小板功能障碍,其机制可能为:药物直接抑制骨髓巨核细胞致使血小板生成障碍;药物直接或通过免疫机制引起血小板的破坏;药物结构或作用导致血小板参与的凝血过程受损。治疗之首要是立即停用相关药物,严重病例可使用输注血小板、激素、丙种球蛋白甚或血浆置换。更多还原

【Abstract】 Drug induced thrombocytopenic syndrome is a common adverse effect of drug therapy.Part of anti-bacterial agents can cause significant thrombocytopenia or thrombocyte dysfunction,depending on the possible mechanisms such as:drugs directly inhibit bone marrow megakaryocytes;drugs destruct platelets directly or through immune mechanisms;structure of drugs or effect of drug destroy the blood coagulation, which platelets involved in.when drug induced thrombocytopenic syndrome were caused by the antibacterial agents,immediately disable drugs.Severe cases can use the infusion of platelets hormones of gammaglobulin or even plasma replacement.更多还原