【作者】 王春华； 徐艳岩； 孙居锋； 侯桂革； 刘文帅；

【Author】 WANG Chunhua;XU Yanyan;SUN Jufeng;Hou Guige;LIU Wenshuai (School of Pharmacy,Binzhou Medical University,Yantai 264003,Shandong)

【机构】 滨州医学院药学院；

【摘要】 以N-甲基二乙醇胺为原料合成了N-甲基-N-十四烷基-N、N-二羟乙基溴化铵和N-甲基-N-十六烷基-N、N-二羟乙基溴化铵两种双羟烷基基季铵盐(QAS)。采用红外光谱、核磁共振谱技术对所合成的化合物进行了结构表征,并研究了其对金黄色葡萄球菌、枯草芽孢杆菌和大肠杆菌的抗菌性能。研究结果表明,在所研究的细菌种类范围内,两种季铵盐都具有良好的抗菌效果。更多还原

【Abstract】 Two quaternary ammonium salt beating dihydroxy alkyl with anti- bacterial activity were synthesized using N - methyl diethanolamine(MDEA) and halogenated hydrocarbon(RX) as raw materials,namely N - methyl - N - tetradecyl - N,N - bis(2 - hydroxyethyl) mmonium bromide,N - methyl - N - hexadecyl - N,N - bis(2 - hydroxyethyl) ammonium bromide.Their structures were characterized by fourier transform infrared spectroscopy(FTIR) and nuclear magnetic resonance hydrogen spectrum(H - NMR);and their antibacterial properties against S.aureus,B.subtilis and E.coli were tested.The test results indicate that the two compounds have good antibacterial activity.更多还原