【作者】 曹瑛； 薛耀明； 沈洁； 高方； 罗祥蓉； 付霞军； 李际敏；

【Author】 Caoying;Xue yaoming;Shenjie;Gaofang;Luo xiangrong;Fu xiajun;Li jimin;Department of Endocrinology, Nanfang Hospital,Southern Medical University;

【机构】 南方医科大学南方医院内分泌代谢科；

【摘要】 目的:探讨血糖波动与痛性神经病变(painful diabetic neuropathy PDN)患者痛域及疼痛程度的关系。方法:对16例PDN患者采用McGill疼痛评分分为轻中度病变组和重度病变组。对两组患者进行痛阈测定并行动态血糖监测,计算24h平均血糖水平(MBG)、标准差(SD)、血糖波动最大幅度(DMMG)、平均血糖波动幅度(MAGE),并测空腹血糖(FBG)、糖化血红蛋白(HbA1C)。结果:糖尿病痛性神经病变患者的SD、DMMG、MAGE均显著高于轻中度病变组(P<0.05),且与疼痛评分呈显著正相关关系。两组间MBG、FBG及HbA1c无显著差异(P>0.05)。结论:血糖波动与PDN疼痛程度有关,积极控制血糖波动有助于对PDN的治疗和预防。更多还原

【Abstract】 Objective:To evaluate the relationship between blood glucose fluctuation and painful diabetic neuropathy.Methods:The pain degrees of the 16 patients were assessed with visual analog scale(VAS) and according to the pain degrees,the patients were divided into mild to moderate pain group and severe pain group.The blood glucose levels of the patients were monitored continuously with contin- uous glucose monitoring system for 72 hours,then the MBG,SD,DMMG,MAGE,AUCPG were obtained.The FBG and HbA1 C were tested.Results:The SD,DMMG,MAGEof the severe pain group were all significantly higher than those of mild to moderate pain group(the P values were all less than 0.05.There were no significant difference in MBG,FBG and HbA1 c between the two groups.Conclusion:The blood glucose fluctuation is correlated to the pain degree,The active control of the blood glucose fluctuation is helpful to prevent and treat PDN.更多还原