【作者】 罗雁红； 雷培芸； 熊丰； 朱岷； 王栋刚； 杨渝生；

【Author】 Yan-hong LUO;Pei-yun LEI;Feng XIONG;Min ZHU;Dong-gang WANG;Yu-sheng YANG;Department of Endocrine,the Childern’ s Hospital, Chongqing Medical University;

【机构】 重庆医科大学附属儿童医院内分泌科；

【摘要】 目的:探讨尿白蛋白(albumin,ALB)、尿Tamn-Horsfal蛋白(Tamn-Horsfal protein,THP)、尿免疫球蛋白G(immunoglobulin G,IgG)、尿β2微球蛋白(β2-microgiobulin,β2MG)在儿童自身免疫性甲状腺疾病(autoimmune thyroid disease,AITD)早期肾损害诊断中的意义。方法:检测93例AITD患儿(包括45例甲状腺功能亢进患儿和48例慢性甲状腺炎患儿)尿ALB、THP、IgG、β2MG水平,并与35例单纯性甲状腺肿及33例正常健康儿童进行比较。结果:AITD慢性甲状腺炎组患儿尿IgG显著高于单纯性甲状腺肿组及正常对照组(P<0.05);慢性甲状腺炎组尿ALB明显高于单纯性甲状腺肿组及正常对照组(P<0.05);AITD患儿及单纯性甲状腺肿组患儿尿β2MG均明显高于正常对照组(P<0.05);AITD患儿及单纯性甲状腺肿组患儿尿THP均高于正常对照组,但差异无统计学意义(P>0.05)。结论:尿ALB、THP、IgG、β2MG是诊断AITD早期肾损害诊断的有效指标。更多还原

【Abstract】 Objective:To investigate the clinical significance of urinary albumin(ALB),Tamn-Horsfal protein(THP),immunoglobulin G(IgG) and urinary β 2-microgiobulin(β 2MG) in the diagnosis of early renal impairment in autoimmune thyroid disease.Methods:Concentrations of urinary ALB,THP,IgG and β 2MG were measured in 33 healthy controls,35 patients with simple goiter and 93 patients with autoimmune thyroid disease-related nephropathy(including 45 patients with hyperthyroidism and 48 patients with chronic lymphocytic thyroiditis).Results:The urinary IgG levels in patients with chronic lymphocytic thyroiditis were significantly increased compared with both healthy controls and the patients with simple goiter(P<0.05),while the urinary ALB concentrations in patients with chronic lymphocytic thyroiditis were higher than those in patients with simple goiter and in the healthy controls(P<0.05).Compared with healthy controls,the patients with autoimmune thyroid disease nephropathy and simple goiter had a significant higher level of P 2MG(P<0.05) and showed a trend towards increased urinary THP(P>0.05).Coaclusion:Urinary ALB,THP,IgG and β 2MG are valuable markers in the diagnosis of early renal impairment caused by autoimmune thyroid disease.更多还原