【作者】 曹瑛； 薛耀明； 赖西南； 高方； 沈洁； 谢翠华；

【Author】 Caoying;Xue yaoming;Lai xinan;Gaofang;Shenjie;Xiecuihua;Department of Endocrinology, Nanfang Hospital, Southern Medical University;Research Institute of Field Surgery, Daping Hospital, Third Military Medical University;

【机构】 南方医科大学南方医院内分泌代谢科； 第三军医大学大坪医院野战外科研究所；

【摘要】 目的:评价超声清创仪对糖尿病足溃疡创面细菌的清除作用及对微循环影响,探讨其可能的促愈机制。方法:采用随机对照法将2008年5月至2009年2月住院的糖尿病足患者24例随机分为标准治疗+普通冲洗组(简称标准治疗组)和标准治疗+超声清创组(简称超声清创组)各1 2例,分别对两组治疗20天内溃疡愈合速度、创面微循环改变及创面细菌清除作用进行比较。结果:1、超声清创组第2 0天平均创面愈合速率0.8 7±0.11,显著快于标准治疗组0.65±0.1 4(P<0.05)。2、超声清创组治疗后创面平均血流灌注量0.91±0.1 8PU及经皮氧分压34.66±6.08,显著高于标准治疗组的0.80±0.19和32.83±6.97(P<0.05)3、超声清创组治疗后创面细菌量显著少于标准治疗组(P<0.05)。结论:超声清创术可通过减轻伤口细菌负荷及促进创面微循环而促进糖尿病足的伤口愈合。更多还原

【Abstract】 Objective:To evaluate the effect of ultrasound debridement apparatus in the treatment of diabetic foot ulcer and study the probable mechanism of healing promotion.Methods:24 patients with diabetic foot ulcer,who were hospitalized from May,2008 to February,2009,were randomized into standard therapy plus common washing group(standard therapy group) and standard therapy plus ultrasound debridement group(ultrasound debridement group).There were 12 patients in each group.The speed of ulcer healing,microcirculation change of wound surface,bacterial on wound surface in 20 days were compared between the two groups.Results:1.The average healing speed of wound surface on day 20 of ultrasound debridement group and standard therapy group were 0.87±0.11and0.65±0.14 respectively,the former were significantly higher.(P<0.05).2.The average blood perfusion volume of wound surface and transcutaneous oxygen pressure of ultrasound debridement group were 0.91 ± 0.18 PU and 34.66 ±6.08 respectively,which were significantly higher than those(0.80 ± 0.19 PU,32.83 ± 6.97) of standard therapy group(P<0.05).3,The bacterial counts on wound surface of ultrasound debridement group were significantly fewer than those of standard therapy group(P<0.05).Conclusion:Ultrasound debridement can promote the healing of diabetic foot ulcer through decreasing the bacterial load of wound surface and accelerating the microcirculation of wound surface.更多还原